UCLA Memory Clinic

Supported by the UCLA Departments of Molecular and Medical Pharmacology and Psychiatry and Biobehavioral Sciences, the UCLA Memory Clinic provides state-of-the-art care for people suffering from age-related memory decline and promotes innovative research and professional education on early detection and prevention of these conditions, emphasizing advanced functional brain imaging, genetic, and other relevant technologies. cognitive function, treatment/no treatment

Patients are provided a unique clinical service and are potential research participants. UCLA faculty and trainees learn about new discoveries, integrate them into their own clinical practices, and participate as co-investigators in studies advancing understanding and practical application of early dementia detection and prevention.

The annual estimated cost of dementia in the U.S. alone is $100 billion. Delaying memory decline and onset of Alzheimer's by just a year would save billions and improve quality of life for patients and their families. The Clinic's impact will be considerable in helping a large number of middle-aged and older people improve and maintain healthy mental function and remain active in the community.

Clinic Personnel

Director: Gary Small, M.D.
Psychiatry Faculty: Helen Lavretsky, M.D., Stephen Read, M.D. Jennifer Dunkin, Ph.D., Michael Kozart, M.D., Janet Conney, M.D., Ibrahim Gunay, M.D.
Pharmacology/Nuclear Medicine Faculty: Johannes Czernin, M.D., Daniel Silverman, M.D.
Staff: Andrea Kaplan, Deborah Dorsey, R.N., M.N., Rose Yamazaki, Pharm.D., Linda Ercoli, Ph.D., Karen Miller, Ph.D., Valerie Kenyon, Kilby De Witt, Gwendolym Byrd, M.A.
Advisory Group: Peter Whybrow, M.D., Fawzy Fawzy, M.D., James Spar, M.D., Michael Phelps, Ph.D., Jeffrey Cummings, M.D.

Current Clinical Research Programs

Research focuses on mild memory losses associated with aging, Alzheimer's disease, and other forms of dementia. Currently, people with or without memory complaints may volunteer. Research participants are paid $25.00 each visit.

Anti-Inflammatory Treatment for Slowing Memory Decline

This study follows up on earlier work suggesting that anti-inflammatory treatment may reduce the risk for Alzheimer's disease. People with mild memory complaints over age 50 years are eligible to participate. After receiving a PET and MRI scan, volunteers receive either the anti-inflammatory drug Celebrex or placebo (inactive compound). Return visits are scheduled every 3 months and scans are repeated after two years.

Anti-Alzheimer's Treatment for Slowing Memory Decline

This study has a design similar to the anti-inflammatory treatment study. People with mild memory complaints over age 50 years are eligible to participate. After receiving a PET and MRI scan, volunteers receive either the anti-AlzheimerÍs drug Aricept or placebo. Return visits are scheduled every 3 months and scans are repeated after two years.

PET Imaging of Plaques and Tangles in Alzheimer's Disease, Other Dementias, and in Normal Persons

This project uses PET to image the actual underlying lesions that define Alzheimer's: the amyloid plaques and neurofibrillary tangles. Volunteers receive two PET scans (a standard scan and a second amyloid imaging scan), an MRI, and memory assessments. Different forms of mild memory loss, and dementia (e.g., Alzheimer's, Lewy Body, etc.) are studied.

Treatment of Late-Life Depression with Celexa or Placebo

Older persons sometimes develop mood and memory symptoms, but information on geriatric depression treatments in people over age 75 years is limited. This study will provide insights on treatment of late-life depression in this older age group. Volunteers receive either a newly available antidepressant or placebo.

Functional MRI Cognitive Stress Test

In these studies, the conventional MRI scanner is modified so that it shows changes in cerebral blood flow while volunteers perform memory tasks. Many participants in other brain imaging studies (e.g., PET scanning) also agree to participate in these investigations. The procedure takes approximately one hour.

Memory Training Studies

Volunteers receive an 8-week memory training course or mental stimulation through computer games and other activities. Memory performance is assessed before and after these activities.

Services and Educational Programs

In addition to ongoing memory research, the Clinic provides assessments and treatment for a wide range of age-related memory problems, particularly milder memory loss conditions. Volunteers also have access to lectures and seminars on aging, memory training, Alzheimer's disease, and caregiving. Professional education on functional brain imaging, genetics and clinical assessment and treatment are also available.

For More Information or To Schedule an Appointment:

Call (310) 825-9897 or email vkenyon@mednet.ucla.edu.


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